Longitudinal associations between sleep disturbance and disease severity in patients with COPD

Abstract

Sleep disturbance is a common complaint among patients with chronic obstructive pulmonary disease (COPD). Studies examining the associations between sleep disturbance and COPD severity have primarily been cross-sectional and produced conflicting results. We extended previous research by investigating the bidirectional longitudinal associations between sleep disturbance and indicators of COPD severity including airway obstruction, dyspnea, health status, exercise capacity, hyperinflation, and diffusing capacity of the lung (DLCO).