Dammarane triterpenes of Commiphora confusa resin

Abstract

Fractionation of a steam distilled residue of Commiphora confusa resin has yielded four novel dammarane triterpenes characterised as (20S)-3β-acetoxy- 12β,16β-trihydroxydammar-24-ene, (20S)-12β,16β- trihydroxydammar-24-ene-3β-O-β-glucopyranoside, (20S)-3β-acetoxy- 12β,16β,25-tetrahydroxydammar-23-ene, and (20S)-3β,12β, 16β,25-pentahydroxydammar-23-ene. The known compounds β-amyrin, 3β-amyrinacetate, 2-methoxyfuranodienone, 2-acetoxyfuranodienone, (20R)-3β-acetoxy-16β-dihydroxydammar-24-ene, (20R)-3β,16β- trihydroxydammar-24-ene, 3β-acetoxy-16β-hydroxydammar-24-ene, 3β-hydroxydammar-24-ene, 3β-acetoxydammar-24-ene, and β-sistosterol were also isolated from the same extract. The structures of the compounds were determined using spectroscopic, physical, and chemical methods. © 2003 Pharmaceutical Society of Japan.