Mitochondrial Cl--Selective Fluorescent Probe for Biological Applications

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Abstract

Herein we describe the development of the first mitochondrial Cl-selective fluorescent probe, Mito-MQAE, and its applications in biological systems. Fluorescence of Mito-MQAE is insensitive to pH over the physiological pH range and is quenched by Cl- with a Stern-Volmer quenching constant of 201 M-1 at pH 7.0. The results of cell studies using Mito-MQAE show that substances with the ability to disrupt mitochondrial membranes cause increases in the mitochondrial Cl- concentration.

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Park, S. H., Shin, I., Kim, Y. H., & Shin, I. (2020). Mitochondrial Cl--Selective Fluorescent Probe for Biological Applications. Analytical Chemistry, 92(18), 12116–12119. https://doi.org/10.1021/acs.analchem.0c02658

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