Chiral separations by countercurrent chromatography

Abstract

Chiral separations by countercurrent chromatography are mainly divided into two types: Homogeneous chiral selector addition and interfacial chiral ligand exchange. In this chapter, we describe two methods for the enantioseparation of phenylsuccinic acid and α-hydroxy acids by high-speed countercurrent chromatography using hydroxypropyl-β-cyclodextrin and N-n-dodecyl-l-proline as chiral selectors for both above mentioned modes.