IntroVerse: a comprehensive database of introns across human tissues

4Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Dysregulation of RNA splicing contributes to both rare and complex diseases. RNA-sequencing data from human tissues has shown that this process can be inaccurate, resulting in the presence of novel introns detected at low frequency across samples and within an individual. To enable the full spectrum of intron use to be explored, we have developed IntroVerse, which offers an extensive catalogue on the splicing of 332,571 annotated introns and a linked set of 4,679,474 novel junctions covering 32,669 different genes. This dataset has been generated through the analysis of 17,510 human control RNA samples from 54 tissues provided by the Genotype-Tissue Expression Consortium. IntroVerse has two unique features: (i) it provides a complete catalogue of novel junctions and (ii) each novel junction has been assigned to a specific annotated intron. This unique, hierarchical structure offers multiple uses, including the identification of novel transcripts from known genes and their tissue-specific usage, and the assessment of background splicing noise for introns thought to be mis-spliced in disease states. IntroVerse provides a user-friendly web interface and is freely available at https://rytenlab.com/browser/app/introverse.

References Powered by Scopus

RNA-Seq: A revolutionary tool for transcriptomics

9713Citations
N/AReaders
Get full text

Alternative isoform regulation in human tissue transcriptomes

3951Citations
N/AReaders
Get full text

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

2905Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1

3Citations
N/AReaders
Get full text

FLIBase: a comprehensive repository of full-length isoforms across human cancers and tissues

2Citations
N/AReaders
Get full text

Steering research on mRNA splicing in cancer towards clinical translation

1Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

García-Ruiz, S., Gustavsson, E. K., Zhang, D., Reynolds, R. H., Chen, Z., Fairbrother-Browne, A., … Ryten, M. (2023). IntroVerse: a comprehensive database of introns across human tissues. Nucleic Acids Research, 51(D1), D167–D178. https://doi.org/10.1093/nar/gkac1056

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 4

57%

Professor / Associate Prof. 3

43%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 4

57%

Agricultural and Biological Sciences 1

14%

Computer Science 1

14%

Neuroscience 1

14%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free