Difference in the Level of p-Selectin Blood Edge between Uni-Valvular and Multivalvular in Rheumatic Heart Disease

Abstract

Rheumatic heart disease remains a major medical problem of children and young adults. Rheumatic heart disease is sequelae of acute rheumatic fever, a bacterial infection Group A beta Hemolitiycus streptococci (GAS) in the pharynx. It is based on genetic predisposition and an autoimmune process causing defect of heart valves, hemodynamic changes, endothelial damage. Further, it is usually illustrated by elevated levels of P selectin. This study was conducted to prove the difference between peripheral P selectin level in multivalve and univalve (mitral stenosis) in rheumatic heart disease. This cross sectional study involving 37 RHD patients consists of 18 univalve (mitral stenosis), 19 multivalve, and 22 healthy controls. P selectin levels were collected through peripheral vein and echocardiography was performed. Peripheral P selectin was significantly higher in univalve and multivalve rheumatic heart disease than normal. Peripheral P selectin in multivalve group was higher than univalve group (2,384ng/mL vs 2,028ng/mL; ρ < 0.05). There was significant difference of peripheral P selectin between multivalve and univalve (mitral stenosis). P selectin potentially has an important role as an indicator of inflammation and progression of valve damage in mitral stenosis, rheumatic heart disease.