Olfactory bulb deep short-axon cells mediate widespread inhibition of tufted cell apical dendrites

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Abstract

In the main olfactory bulb (MOB), the first station of sensory processing in the olfactory system, GABAergic interneuron signaling shapes principal neuron activity to regulate olfaction. However, a lack of known selective markers for MOB interneurons has strongly impeded cell-type-selective investigation of interneuron function. Here, we identify the first selective marker of glomerular layer-projecting deep short-axon cells (GL-dSACs) and investigate systematically the structure, abundance, intrinsic physiology, feedforward sensory input, neuromodulation, synaptic output, and functional role of GL-dSACs in the mouse MOB circuit. GL-dSACs are located in the internal plexiform layer, where they integrate centrifugal cholinergic input with highly convergent feedforward sensory input. GL-dSAC axons arborize extensively across the glomerular layer to provide highly divergent yet selective output onto interneurons and principal tufted cells. GL-dSACs are thus capable of shifting the balance of principal tufted versus mitral cell activity across large expanses of the MOB in response to diverse sensory and top-down neuromodulatory input.

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APA

Burton, S. D., LaRocca, G., Liu, A., Cheetham, C. E. J., & Urban, N. N. (2017). Olfactory bulb deep short-axon cells mediate widespread inhibition of tufted cell apical dendrites. Journal of Neuroscience, 37(5), 1117–1138. https://doi.org/10.1523/JNEUROSCI.2880-16.2016

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