Retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) are cytosolic RNA helicases that sense viral RNA and trigger signaling pathways that induce the production of type I interferons (IFNs) and proinf ammatory cytokines. RLRs recognize distinct and overlapping sets of viruses, but the mechanisms that dictate this specif city were unknown. A new study now provides evidence for size-based discrimination of double-stranded RNA (dsRNA) by RLRs and suggests how host cells recognize a variety of RNA viruses.
CITATION STYLE
Proceedings of the International Conference on Computing, Mathematics and Statistics (iCMS 2015). (2017). Proceedings of the International Conference on Computing, Mathematics and Statistics (iCMS 2015). Springer Singapore. https://doi.org/10.1007/978-981-10-2772-7
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