Fully electronic urine dipstick probe for combinatorial detection of inflammatory biomarkers

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Abstract

Aim: An electrochemical urine dipstick probe biosensor has been demonstrated using molybdenum electrodes on nanoporous polyamide substrate for the quantitative detection of two inflammatory protein biomarkers, CRP and IL-6. Materials & methods: The electrode interface was characterized using ζ-potential and Fourier transform infrared spectroscopy. Detection of biomarkers was demonstrated by measuring impedance changes associated with the dose concentrations of the two biomarkers. A proof of feasibility of point-of-care implementation of the biosensor was demonstrated using a portable electronics platform. Results & conclusion: Limit of detection of 1 pg/ml was achieved for CRP and IL-6 in human urine and synthetic urine buffers. The developed portable hardware demonstrated close correlation with benchtop equipment results.

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Kamakoti, V., Kinnamon, D., Choi, K. H., Jagannath, B., & Prasad, S. (2018). Fully electronic urine dipstick probe for combinatorial detection of inflammatory biomarkers. Future Science OA, 4(5). https://doi.org/10.4155/fsoa-2017-0142

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