Hypoadiponectinemia is associated with coronary artery spasm in men

Abstract

Background: The relationship between adiponectin and coronary spastic angina (CSA), both of which are closely involved in coronary endothelial dysfunction, has not been elucidated. Methods and Results: Plasma adiponectin concentrations were examined in 55 men with CSA and 55 with chest pain syndrome (CPS). The plasma log-adiponectin levels were significantly lower in patients with CSA than with CPS (0.61±0.28 vs 0.80±0.21• g•/ml, p<0.0001). The prevalence of smoking was significantly higher in the CSA patients than in those with CPS (50.9% vs 29.1%, p=0.0195). In multiple logistic regression analysis, log-adiponectin (p=0.0008) and smoking (p=0.0210) were independent determinants of CSA. Conclusions: Hypoadiponectinemia is a potential risk factor for CSA in men, independent of smoking.