Abstract
Dengue viruses are arthropod-borne, single-stranded RNA viruses. Ae ëdes aegypti and Ae ëdes albopictus are the principal vectors. In order to understand the molecular basis of dengue virus infections we explored the biochemical identity of dengue-2 (DEN-2) virus receptors in the Ae ëdes albopictus-derived cell line C6/36. We show here that DEN-2 interacts with two major polypeptides of 80 and 67 kDa. Polyclonal anti-C6/36 membrane antibodies block DEN-2 binding to intact C6/36 monolayers as well as to membrane extracts. Our results strongly suggest that the identified polypeptides are part of the DEN-2 receptors. z 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
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CITATION STYLE
Lourdes Muñoz, M., Cisneros, A., Cruz, J., Das, P., Tovar, R., & Ortega, A. (1998). Putative dengue virus receptors from mosquito cells. FEMS Microbiology Letters, 168(2), 251–258. https://doi.org/10.1111/j.1574-6968.1998.tb13281.x
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