Abstract
A number of derivatives of the cyclopropenone antibiotic penitricin have been synthesized by the reaction of metalated cyclopropenone acetals with electrophiles. Studies on the antimicrobial structure-activity relationships indicated that the penitricin skeleton, hydroxymethylcyclopropenone, is indispensable for antimicrobial activity. These compounds were also found to display cytotoxic activity. © 1992, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.
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CITATION STYLE
Tokuyama, H., Isaka, M., Nakamura, E., Ando, R., & Morinaka, Y. (1992). Synthesis and biological activities of cyclopropenone antibiotic penitricin and congeners. The Journal of Antibiotics, 45(7), 1148–1154. https://doi.org/10.7164/antibiotics.45.1148
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