The concept of "vasculogenic mimicry" (VM) was introduced to describe the unique ability of highly aggressive tumor cells to form capillary-like structure (CLS) and matrix-rich patterned network in three-dimensional cultures that mimic embryonic vasculogenic network. Here, we provide the experimental evidence that CLS structure formation requires apoptotic cell death through activation of caspase-dependent mechanism. Our results indicate that the formation of CLS is also related to the reactive oxygen species (ROS) levels. © 2007 Springer Science+Business Media, LLC.
CITATION STYLE
Vartanian, A., & Baryshnikov, A. Y. (2007). Crosstalk between apoptosis and antioxidants in melanoma vasculogenic mimicry. In Advances in Experimental Medicine and Biology (Vol. 601, pp. 145–153). https://doi.org/10.1007/978-0-387-72005-0_15
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