The role of fluorine- 18-fluorodeoxyglucose positron emission tomography in staging and restaging of patients with osteosarcoma

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Abstract

Background. The objective of this study is to systematically review the role of positron emission tomography (PET) and PET/computed tomography (PET/CT) with Fluorine- 18-Fluorodeoxyglucose (FDG) in patients with osteosarcoma (OS). Methods. A comprehensive literature search of published studies through October lO*. 2012 in PubMed/MEDUNE, Embase and Scopus databases regarding whole-body FDG-PET and FDG-PET/CT in patients with OS was performed. Results. We identified 13 studies including 289 patients with OS. With regard to the staging and restaging of OS, the diagnostic performance of FDG-PET and PET/CT seem to be high; FDG-PET and PET/CT seem to be superior to bone scintigraphy and conventional imaging methods in detecting bone metastases; conversely, spiral CT seems to be superior to FDG-PET in detecting pulmonary metastases from OS Conclusions. Metabolic imaging may provide additional information in the evaluation of OS patients. The combination of FDG-PET or FDG-PET/CT with conventional imaging methods seems to be a valuable tool in the staging and restaging of OS and may have a relevant impact on the treatment planning.

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Quartuccio, N., Treglia, G., Salsano, M., Mattoli, M. V., Muoio, B., Piccardo, A., … Cistaro, A. (2013). The role of fluorine- 18-fluorodeoxyglucose positron emission tomography in staging and restaging of patients with osteosarcoma. Radiology and Oncology. Sciendo. https://doi.org/10.2478/raon-2013-0017

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