Oral Prostaglandin E1 Derivative (OP-1206) in an Infant with Double Outlet Right Ventricle and Pulmonary Stenosis: Effect on Ductus-Dependent Pulmonary Circulation

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Abstract

A small-for-gestational-age infant with cyanosis due to double outlet right ventricle with severe pulmonary stenosis and patent ductus arteriosus was treated with oral prostaglandin E1 derivative (OP-1206). The constricting ductus arteriosus dilated and the ductus-dependent pulmonary blood flow increased. The recommended dosage was 1.5-2.0 μg/kg/day which was lower than that of intravenous PGE1 or of oral PGE2. The administration interval was 6 hours, which was longer than that of oral PGE2. The patient was treated as an out-patient because continuous intravenous infusion was not necessary. Treatment was continued for 2 months without complication, at which time a Blalock-Taussig shunt operation was performed. Orally administered PGE1 derivative (OP-1206) was found to be equally effective to intravenous infusion of PGE1 for both short and long-term management of cyanotic heart disease in which the pulmonary blood flow is mostly dependent on the patency of the ductus arteriosus. Oral PGE1 derivative (OP-1206) may be a possible substitute for intravenous PGE1 infusion therapy. © 1991, International Heart Journal Association. All rights reserved.

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APA

Saji, T., Matsuura, H., Hoshino, K., Yamamoto, S., Ishikita, T., & Matsuo, N. (1991). Oral Prostaglandin E1 Derivative (OP-1206) in an Infant with Double Outlet Right Ventricle and Pulmonary Stenosis: Effect on Ductus-Dependent Pulmonary Circulation. Japanese Heart Journal, 32(5), 735–740. https://doi.org/10.1536/ihj.32.735

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