Gestational diabetes mellitus (GDM), one of the most common complications during pregnancy, is associated with a high risk of short-and long-term adverse effects on the mother and offspring. Placenta-derived hormones and cytokines aggravate maternal insulin resistance (IR) during pregnancy, which in turn contribute to GDM. The hypergly-cemia and IR in GDM result in aberrant placental structure and function adversely affecting fetal growth and well-being. Therefore, it is reasonable to assume that structural and functional alterations in the placenta contribute to the pathogenesis of GDM and GDM-related complications. Increasing evidence suggests that multiple non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are dysregu-lated in placentas of patients with GDM and linked to abnormal placental structure, meta-bolism, and function. Manipulation of ncRNA expression led to some key pathophysiological features of GDM, such as trophoblast dysfunction, changes in intracel-lular glucose metabolism, and inflammation. Moreover, placenta-specific ncRNAs may be potential diagnostic biomarkers and even therapeutic targets for GDM. This review sum-marizes data published on the involvement of aberrantly expressed placental ncRNAs in GDM and provides information on their role in the pathogenesis of GDM and GDM-associated complications.
CITATION STYLE
Du, R., Wu, N., & Li, L. (2021). Aberrantly expressed non-coding RNAs in the placenta and their role in the pathophysiology of gestational diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity. Dove Medical Press Ltd. https://doi.org/10.2147/DMSO.S325993
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