Analysis Of The Relationship Between HBA1C and Serum Galectin-3 Levels in Subjects With Type 2 Of Diabetes Mellitus

Abstract

Type 2 diabetes mellitus is a disease characterized by increased blood glucose levels known as hyperglycemia. This disease can be diagnosed by examining HbA1c (glycated hemoglobin). Hemoglobin A1c is a minor component of hemoglobin related to glucose. Meanwhile, galectin-3 is a protein encoded in humans by the LGALS3 gene. This study aimed to clarify the relationship between HbA1c and serum galectin-3 levels in patients with type 2 diabetes. This study was conducted using an observational analysis technique with a cross-sectional study design . This research was conducted at the Clinical Pathology Laboratory, Hasanuddin University State University Hospital, and Laboratorium Universitas Hasanuddin Medical Research Center State College Hospital Universitas Hasanuddin Makassar . This research was conducted from January to March 2023 . The population in this study were all patients with type 2 DM who visited the Hasanuddin University Hospital (RSPTN-UH) for treatment a total of 112 patients . Research sampling technique with non-probability purposive sampling. The sample of this study was 60 patients. Data analysis with the Independent T-test or Mann-Whitney test. The results of the study were that serum Galectin-3 levels in uncontrolled type 2 diabetes mellitus had a higher average value of 20.18 ± 6.15 ng/mL compared to controlled type 2 diabetes mellitus, namely 14.80 ± 6.41 ng/ mL although there was a statistically significant difference (p=0.012) but no significant correlation was found between HbA1c and serum Galectin-3 levels in type 2 diabetes mellitus subjects (r=0.176 p=0.179) with the distribution of data in the Scatterplot not forming a linear relationship pattern . It is recommended that type 2 Diabetes Mellitus patients carry out an HbA1c examination as an effective test to control glucose levels, reduce the risk of complications, and maintain a healthy lifestyle to avoid type 2 DM. Keyword: HbA1c, Serum Galectin-3, Type 2 Diabetes Mellitus