Objectives To determine the relationship between lung function impairment and quantitative computed tomography (CT) measurements of air trapping and emphysema in a population of current and former heavy smokers with and without airflow limitation. Methods In 248 subjects (50 normal smokers; 50 mild obstruction; 50 moderate obstruction; 50 severe obstruction; 48 very severe obstruction) CT emphysema and CT air trapping were quantified on paired inspiratory and end- expiratory CT examinations using several available quantification methods. CT measurements were related to lung function (FEV 1, FEV 1/FVC, RV/TLC, Kco) by univariate and multivariate linear regression analysis. Results Quantitative CT measurements of emphysema and air trapping were strongly correlated to airflow limitation (univariate r-squared up to 0.72, p<0.001). In multivariate analysis, the combination of CT emphysema and CT air trapping explained 68-83% of the variability in airflow limitation in subjects covering the total range of airflow limitation (p<0.001). Conclusions The combination of quantitative CT air trapping and emphysema measurements is strongly associated with lung function impairment in current and former heavy smokers with a wide range of airflow limitation. © The Author(s) 2011.
CITATION STYLE
Mets, O. M., Murphy, K., Zanen, P., Gietema, H. A., Lammers, J. W., Van Ginneken, B., … De Jong, P. A. (2012). The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease. European Radiology, 22(1), 120–128. https://doi.org/10.1007/s00330-011-2237-9
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