Multiscale Modelling of Lymphatic Drainage

Abstract

In this chapter we will describe the latest developments in the area of lymphatic modelling. The lymphatic system is one of the key elements of the human circulation, serving the dual functions of draining interstitial fluid and returning this to the general blood circulation, together with processing this lymph fluid which is a key component of the body’s immune response system. Compared to the main cardiovascular system however, remarkably little modelling has been attempted. At the same time, the distribution of pumping activity (contractile lymphangions coupled with simple valves) throughout the system, passive primary lymphatics and complex lymph nodes combining to form an active network, makes the system a prime candidate for multiscale modelling.