Current Status and Future Targeted Therapy in Adrenocortical Cancer

24Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. The current treatment standards include complete surgical resection for localized resectable disease and systemic therapy with mitotane alone or in combination with etoposide, doxorubicin, and cisplatin in patients with advanced ACC. However, the efficacy of systemic therapy in ACC is very limited, with high rates of toxicities. The understanding of altered molecular pathways is critically important to identify effective treatment options that currently do not exist. In this review, we discuss the results of recent advanced in molecular profiling of ACC with the focus on dysregulated pathways from various genomic and epigenetic dysregulation. We discuss the potential translational therapeutic implication of molecular alterations. In addition, we review and summarize the results of recent clinical trials and ongoing trials.

References Powered by Scopus

Cited by Powered by Scopus

Get full text
16Citations
39Readers
8Citations
10Readers
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Alyateem, G., & Nilubol, N. (2021, March 1). Current Status and Future Targeted Therapy in Adrenocortical Cancer. Frontiers in Endocrinology. Frontiers Media S.A. https://doi.org/10.3389/fendo.2021.613248

Readers over time

‘21‘22‘23‘24‘25036912

Readers' Seniority

Tooltip

Researcher 4

57%

PhD / Post grad / Masters / Doc 2

29%

Professor / Associate Prof. 1

14%

Readers' Discipline

Tooltip

Medicine and Dentistry 6

55%

Biochemistry, Genetics and Molecular Bi... 3

27%

Pharmacology, Toxicology and Pharmaceut... 1

9%

Nursing and Health Professions 1

9%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free
0