Oxidative Stress and Liver Injury

Abstract

Oxidative stress and liver injury are strongly associated. Oxidative stress in the liver can be triggered during different conditions and by specific etiologies, including hepatotoxins (acetaminophen [1]), viruses (e.g., hepatitis C virus [2]), nonalcoholic steatohepatitis (NASH) [3], hepatocellular carcinoma [4], alcoholic liver disease (ALD) [5], ischemia-­reperfusion, and liver fibrosis [6]. Oxidative stress is a state of imbalance between the production of reactive oxygen species (ROS) and the cellular antioxidant defense neutralizing the reactive intermediates and triggering damage.