GenePANDA-a novel network-based gene prioritizing tool for complex diseases

17Citations
Citations of this article
43Readers
Mendeley users who have this article in their library.

Abstract

Here we describe GenePANDA, a novel network-based tool for prioritizing candidate disease genes. GenePANDA assesses whether a gene is likely a candidate disease gene based on its relative distance to known disease genes in a functional association network. A unique feature of GenePANDA is the introduction of adjusted network distance derived by normalizing the raw network distance between two genes with their respective mean raw network distance to all other genes in the network. The use of adjusted network distance significantly improves GenePANDA's performance on prioritizing complex disease genes. GenePANDA achieves superior performance over five previously published algorithms for prioritizing disease genes. Finally, GenePANDA can assist in prioritizing functionally important SNPs identified by GWAS.

Cite

CITATION STYLE

APA

Yin, T., Chen, S., Wu, X., & Tian, W. (2017). GenePANDA-a novel network-based gene prioritizing tool for complex diseases. Scientific Reports, 7. https://doi.org/10.1038/srep43258

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free