Inner ear organoids: New tools to understand neurosensory cell development, degeneration and regeneration

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Abstract

The development of therapeutic interventions for hearing loss requires fundamental knowledge about the signaling pathways controlling tissue development as well as the establishment of human cell-based assays to validate therapeutic strategies ex vivo. Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how they offer for the first time the opportunity to validate drug-based therapies, gene-targeting approaches and cell replacement strategies.

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Roccio, M., & Edge, A. S. B. (2019). Inner ear organoids: New tools to understand neurosensory cell development, degeneration and regeneration. Development (Cambridge). Company of Biologists Ltd. https://doi.org/10.1242/dev.177188

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