GM-CSF and whole cells

Abstract

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a pleiotropic cytokine critical to immune homeostasis, capable of both pro-inflammatory and tolerance-inducing properties. GM-CSF has a variety of current and potential clinical applications, including use as a growth factor for myeloid cell recovery after chemotherapy, as a cancer vaccine adjuvant, and in combinatorial immunotherapy with monoclonal antibodies.