Anti-Inflamatory Activity of Water Extract of Talinum paniculatum. (Jact). Gaertn Leaves on Wistar Rat

Abstract

Inflammation is the body's protective response to tissue injury caused by harmful agents characterized by edema. Talinum paniculatum (jact.) Gaertn leaves contain secondary metabolites such as flavonoids, steroids, and tannins known to have anti-inflammatory effects. The research aimed to determine the effective dose of Talinum paniculatum (jact.) Gaertn leaves as anti-inflammatory against rats. This research was conducted using rats which were divided into 3 groups: control (prednisone), extract of Talinum paniculatum (jact.) Gaertn leaves at doses of 1 g/kgbw and 2 g/kgbw. The width and thickness of the edema were measured for 5 hours using a caliper to calculate the total AUC value. Then it was analyzed statistically using Kruskal-Wallis test followed by Mann-Whitney test. The results of statistical analysis showed that the group at the dose of 2 g/kgbw had an anti-inflammatory effect not significantly different from the control group. It was concluded that the water extract of Talinum paniculatum (jact.) Gaertn leaves had anti-inflammatory activity at the effective dose of 2 g/kgbw.