Vaccines against human carcinomas: Strategies to improve antitumor immune responses

54Citations
Citations of this article
63Readers
Mendeley users who have this article in their library.

Abstract

Multiple observations in preclinical and clinical studies support a role for the immune system in controlling tumor growth and progression. Various components of the innate and adaptive immune response are able to mediate tumor cell destruction; however, certain immune cell populations can also induce a protumor environment that favors tumor growth and the development of metastasis. Moreover, tumor cells themselves are equipped with various mechanisms that allow them to evade surveillance by the immune system. The goal of cancer vaccines is to induce a tumor-specific immune response that ultimately will reduce tumor burden by tipping the balance from a protumor to an antitumor immune environment. This review discusses common mechanisms that govern immune cell activation and tumor immune escape, and some of the current strategies employed in the field of cancer vaccines aimed at enhancing activation of tumor-specific T-cells with concurrent reduction of immunosuppression. © 2010 C. Palena and J. Schlom.

References Powered by Scopus

The basics of epithelial-mesenchymal transition

8427Citations
N/AReaders
Get full text

Epithelial-mesenchymal transitions in tumor progression

5819Citations
N/AReaders
Get full text

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

5265Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Adjuvants for cancer vaccines

235Citations
N/AReaders
Get full text

The evolving role of immune checkpoint inhibitors in cancer treatment

204Citations
N/AReaders
Get full text

Tumor evasion from T cell surveillance

151Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Schlom, J., & Palena, C. (2010). Vaccines against human carcinomas: Strategies to improve antitumor immune responses. Journal of Biomedicine and Biotechnology. https://doi.org/10.1155/2010/380697

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 28

56%

Researcher 18

36%

Professor / Associate Prof. 4

8%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 26

60%

Medicine and Dentistry 9

21%

Chemistry 4

9%

Biochemistry, Genetics and Molecular Bi... 4

9%

Save time finding and organizing research with Mendeley

Sign up for free