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A novel versipelostatin analogue, versipelostatin F isolated from streptomyces versipellis 4083-SVS6

Journal of Antibiotics (2008) 61(12) 752-755
DOI: 10.1038/ja.2008.89
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Abstract

A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC50 value of 0.3 μM, which is 10-times more potent compared with that of 1. © Japan Antibiotics Research Association.

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Ueda, J. Y., Chijiwa, S., Takagi, M., & Shin-ya, K. (2008). A novel versipelostatin analogue, versipelostatin F isolated from streptomyces versipellis 4083-SVS6. Journal of Antibiotics, 61(12), 752–755. https://doi.org/10.1038/ja.2008.89

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