Collagen breakdown and apoptotic cell death within the apex of the preovulatory ovine follicle are hallmarks of impending ovarian rupture. An integrative mechanism is proposed whereby gonadotrophic stimulation of urokinase-type plasminogen activator secretion by the follicular-contiguous ovarian surface epithelium elicits a localized increase in tissue plasmin, which activates collagenolysis and tumour necrosis factor alpha-induced cell death within the formative ovulatory stigma.
CITATION STYLE
Murdoch, W. J. (1999). Plasmin-tumour necrosis factor interaction in the ovulatory process. Journal of Reproduction and Fertility. Supplement. https://doi.org/10.1530/biosciprocs.4.027
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