β2 Microglobulin in tear fluid from patients with primary Sjogren's syndrome

Abstract

β2 Microglobulin concentration in tear fluid was measured in 35 patients with primary Sjogren's syndrome (SS), in 28 normal control subjects matched for age and sex, and in 18 patients with arthralgias or myalgias and sicca complaints, in whom the diagnosis primary SS had been excluded. Increased β2 microglobulin concentrations were found in the patients with SS, but no correlation was found with the duration of the disease, age, or tear fluid production. Tear fluid β2 microglobulin determinations may be useful as an adjunctive diagnostic test for primary SS.