Melanin Production Inhibitors from the West African Cassipourea congoensis

  • Takou D
  • Waffo A
  • Langat M
  • et al.
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Abstract

Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid 1 and 24-methylenecycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6 , (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 µM with low cytotoxicity validating the ethnomedicinal use of this plant.

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Takou, D. M., Waffo, A. F. K., Langat, M. K., Wansi, J. D., Mulcahy-Ryan, L. E., Schwikkard, S. L., … Mulholland, D. A. (2019). Melanin Production Inhibitors from the West African Cassipourea congoensis. Planta Medica International Open, 6(02), e50–e56. https://doi.org/10.1055/a-1006-2880

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