Cassipourea congoensis (syn. Cassipourea malosana) is used in African countries as a skin-lightening agent. Two previously unreported cycloartane triterpenoids, 26-hydroxy-3-keto-24-methylenecycloartan-30-oic acid 1 and 24-methylenecycloartan-3β,26,30-triol 2 along with the known mahuannin B 3, 7-methoxymahuannin B 4, 7-methoxygeranin A 5, methyl-3-(4-hydroxy-3-methoxyphenyl)-2E-propenoate, glycerol-1-alkanoate, (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enal 6 , (-)-syringaresinol 7, and stigmast-5-en-3-O-β-D-glucoside, were isolated from the roots of C. congoensis. The crude extract and compounds 1 and 5 were found to inhibit the production of melanin at 10 µM with low cytotoxicity validating the ethnomedicinal use of this plant.
CITATION STYLE
Takou, D. M., Waffo, A. F. K., Langat, M. K., Wansi, J. D., Mulcahy-Ryan, L. E., Schwikkard, S. L., … Mulholland, D. A. (2019). Melanin Production Inhibitors from the West African Cassipourea congoensis. Planta Medica International Open, 6(02), e50–e56. https://doi.org/10.1055/a-1006-2880
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