Monoamine modulation of the synaptic inhibition in the hippocampus

Abstract

Changes in the strength of synaptic inhibition have profound effects on the functions of cortical neurones. Accumulating evidence suggests that inhibitory synaptic transmission may be the target of action of monoamines. In the hippocampal dentate gyrus, norepinephrine and serotonin (5-HT) have multiple direct and indirect actions on the presumed inhibitory hilar neurones. These effects are mediated through distinct mechanisms and signalled by different receptor subtypes. The predominant effects of norepinephrine are excitatory and are mediated by β-adrenergic receptors. Accordingly, both the GABA(A)- and GABA(B)-receptor-mediated inhibition in granule cells is enhanced by activation of the β-adrenergic receptor. 5-HT has more complex effects inhibiting a subpopulation of the hilar neurones and exciting other hilar cells. Study of the effects of 5-HT on inhibition in granule cells revealed that 5-HT enhanced Cl-IPSPs and blocked K-IPSPs. These results are in line with the suggestion that Cl- and K-IPSPs in granule cells are generated by two distinct populations of inhibitory neurones.