Reproduction

Abstract

The creation of the GHR-/- mouse (or Laron mouse) has allowed for the elucidation of GH-specific and GH-dependent IGF1 effects on reproduction. Results obtained from -experiments using these mice have confirmed earlier observations in individuals with Laron Syndrome, such as the delayed onset of puberty and morphological differences. The underlying message regarding GH insensitivity with respect to reproduction is that while the lack of GH signaling has effects upon sexual maturation and fertility, eventually the individual attains sexual maturity and is capable of reproduction. This is in stark contrast to the lack of IGF-1 signaling where both male and females are sterile. This difference is most likely due to the effects of local GH-independent IGF-1 production on the respective reproductive organs. © Springer-Verlag Berlin Heidelberg 2011.