We introduce a Markov model for the evolution of a gene family along a phylogeny. The model includes parameters for the rates of horizontal gene transfer, gene duplication, and gene loss, in addition to branch lengths in the phylogeny. The likelihood for the changes in the size of a gene family across different organisms can be calculated in O(N + hM2) time and O(N + M2) space, where TV is the number of organisms, h is the height of the phylogeny, and M is the sum of family sizes. We apply the model to the evolution of gene content in Proteobacteria using the gene families in the COG (Clusters of Orthologous Groups) database. © Springer-Verlag Berlin Heidelberg 2006.
CITATION STYLE
Csürös, M., & Miklós, I. (2006). A probabilistic model for gene content evolution with duplication, loss, and horizontal transfer. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 3909 LNBI, pp. 206–220). Springer Verlag. https://doi.org/10.1007/11732990_18
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