Nanotoxicity of magnesium oxide on human neuroblastoma SH-SY5y cell lines

Abstract

The use of magnesium oxide (MgO) nanoparticles in industrial applications has beenraised over the last decade. However, there is limited toxicology information available regarding theeffects of MgO nanoparticles. In this study, cytotoxicity and neurotoxicity of this nanoparticle onSH-SY5Y cell lines was investigated. In order to assess the cytotoxicity effect, SH-SY5Y cells wereexposed to three different types of MgO nanoparticles (MgO 5, MgO 10 and MgO 24) for 24, 48and 72 h. The concentration of nanoparticles ranges from 1nM to 1mM. Cell viability wasdetermined by MTS assay. Neurotoxicity test was performed to determine the effects of MgOnanoparticles on human neural cells. Results indicated that MgO nanoparticles are not toxic to bothundifferentiated and differentiated SH-SY5Y cells. With further exploration, the safety and healthconcern regarding exposure of MgO nanoparticles can be verified since the increasing of using thisnanoparticle in industry over the time. © (2013) Trans Tech Publications, Switzerland.