A simple and rapid indirect spectrophotometric method for the determination of mesalazine is developed. The method is based on the rapid reduction of known large amount of chromate CrO 4-2 in the presence of mesalazine in acidic medium of 2N H 2 SO 4. The excess amount of chromate is measured after it's reaction with 1,5-diphenylcarbazide which finally gives a pink-violet, water soluble and stable complex, which exhibit a maximum absorption at 546 nm. Beer's law is obeyed in the concentration range from (5-900) µg of mesalazine in a final volume of 25 ml (0.2-36 ppm) with a molar absorbtivity of 1×10 5 l.mol-1 .cm-1 , Sandell's sensitivity index of 0.0015 µg .cm-2 and relative standard deviation ± 0.0848 to ± 0.3155 depending on the concentration level. The proposed method is applied successfully to the assay of mesalazine in its pharmaceutical prepearation (capsules). ﻟﻠ ﺍﻟﻤﺒﺎﺸﺭ ﻏﻴﺭ ﺍﻟﻁﻴﻔﻲ ﺍﻟﺘﻘﺩﻴﺭ ﻤﻴﺯﺍﻻﺯﻴﻥ ﺍﻟﻜﺭﻭﻡ ﻤﻌﻘﺩ ﺒﺎﺴﺘﺨﺩﺍﻡ-5,1-ﻜﺎﺭﺒﺎﺯﻴﺩ ﻓﻨﻴل ﺜﻨﺎﺌﻲ ﺍﻟﻤﻠﺨﺹ ﺍﻟﺒﺤﺙ ﻴﺘﻀﻤﻥ ﺒﺴﻴ ﻤﺒﺎﺸﺭﺓ ﻏﻴﺭ ﻁﻴﻔﻴﺔ ﻁﺭﻴﻘﺔ ﺘﻁﻭﻴﺭ ﻟ ﻭﺴﺭﻴﻌﺔ ﻁﺔ ﺍﻟﻤﻴﺯﺍﻻﺯﻴﻥ ﺘﻘﺩﻴﺭ. ﺘ ﻌﺘﻤـﺩ ﺍﺨﺘـﺯﺍل ﻋﻠـﻰ ﺍﻟﻁﺭﻴﻘـﺔ ﺍﻟﻜﺭﻭﻤﺎﺕ CrO 4-2 ﺍﻟﻜﺒﺭﻴﺘﻴﻙ ﺤﺎﻤﺽ ﺒﺎﺴﺘﺨﺩﺍﻡ ﺍﻟﺤﺎﻤﻀﻲ ﺍﻟﻭﺴﻁ ﻓﻲ ﺍﻟﻤﻴﺯﺍﻻﺯﻴﻥ ﺒﻭﺴﺎﻁﺔ) 2 ﻋﻴﺎﺭﻱ (ﻏﻴﺭ ﺍﻟﻜﻤﻴﺔ ﺘﻘﺩﻴﺭ ﺜﻡ ﻭﻤﻥ ﻭﺒﻴﻥ ﺍﻟﻤﺨﺘﺯﻟﺔ ﻏﻴﺭ ﺍﻟﻜﺭﻭﻤﺎﺕ ﺒﻴﻥ ﺍﻟﻤﺘﻜﻭﻥ ﺍﻟﻤﻠﻭﻥ ﺍﻟﻤﻌﻘﺩ ﺍﻤﺘﺼﺎﺹ ﻁﻴﻑ ﺒﻘﻴﺎﺱ ﺍﻟﻜﺭﻭﻤﺎﺕ ﻤﻥ ﺍﻟﻤﺨﺘﺯﻟﺔ ﺍﻟﻌـﻀﻭﻱ ﺍﻟﻜﺎﺸـﻑ 5,1-ﺍﻟﻤﻭﺠﻲ ﺍﻟﻁﻭل ﻋﻨﺩ ﻜﺎﺭﺒﺎﺯﻴﺩ ﻓﻨﻴل ﺜﻨﺎﺌﻲ 546 ﻨﺎﻨﻭﻤﻴﺘﺭ. ﺍﻟﺘﺭﻜﻴﺯ ﻤﺩﻯ ﻓﻲ ﺒﻴﺭ ﻗﺎﻨﻭﻥ ﺤﺩﻭﺩ ﻜﺎﻨﺕ) 5 (900-ﻤـﺎﻴﻜﺭﻭﻏﺭﺍﻡ ﺍ ﻤﻥ ﻟﻤﻴﺯﺍﻻﺯﻴﻥ ﻨﻬﺎﺌﻲ ﺤﺠﻡ ﻓﻲ 25 ﻤﻠﻠﺘﺭ ، (0.2-36 ppm)
CITATION STYLE
A. Hamdoon, E. (2018). Indirect Spectrophotometric Determination of Mesalazine via Chromate-1,5-Diphenyl carbazide Complex. Rafidain Journal of Science, 27(2), 69–78. https://doi.org/10.33899/rjs.2018.145392
Mendeley helps you to discover research relevant for your work.