Clinical importance of glutathione-s-transferase enzyme polymorphisms in Cancer

Abstract

Glutathione S-transferase ({GST}) enzyme levels, which is the phase {II} enzyme of biotransformation enzyme group, responsible for detoxification of xenobiotics, are associated with the risk of predisposition to various types of cancer as well as diseases such as asthma, diabetes, Parkinson’s. In this review, we attempt to briefly summarize the association with the polymorphisms of {GSTM}1, {GSTT}1, {GSTP}, and specific cancer types.