Uji Perbandingan Aktivitas Antijamur Pityrosporum ovale dari Kombinasi Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa bilimbi L) dan Daun Sirih (Piper betle) dengan Ketokonazol 2%

Abstract

Pityrosporum ovale is microorganism that is suspected as the main cause of dandruff. Betel leaf has been known as an antimicrobial and has been widely used as a natural antiseptic. Betel leaves contain essential oils which the main component consist of phenol and its derivates such as compounds kavikol, kevibetol, karvakrol, eugenol, estragol, metileugenol, tertipen, seskutertipen, fenilpropans and tannins. Betel leaves also contain carotene, thiamine, riboflavin, nicotinic acid, vitamin C, sugars, starch, and amino acids. Cucumber tree extract contains flavonoids and triterpene saponins. Antifungal effectiveness of Averrhoa bilimbi against Pityrosporum ovale has been much research done. This type of research following the experimental research design using the subject Pityrosporum ovale and ethanol extract cucumber tree (Averrhoa bilimbi L.) and betel leaves (Piper betle L.) the method used by the diffusion method of determining the potential antibiotic inhibition zone at a ratio of 1:1 with a concentration of 1%, 5%, 10%, 15% and 20% compared with ketoconazole 2%. Stages of research began with the determination of plants, manufacture of extract cucumber tree (Averrhoa bilimbi L.) and betel leaf (Piper betel L.) by maceration, identification of secondary metabolites by means of testing alkaloids, tannins and flavonoids, extracts of various concentrations of dilution and concentration test minimum inhibitory (MIC) compared with 2% Ketoconazole. Results of the greatest inhibition zone contained at a concentration of 5% with inhibition zone of 12.0mm, but still small when compared with ketoconazole 2%.