In vitro clot lysis activity of different extracts of Mangifera sylvatica Roxb. Leaves

Abstract

The present study was aimed to evaluate the in vitro thrombolytic activity of different extracts of Mangifera sylvatica Roxb. leaves. An in vitro thrombolytic model was used to check the clot lysis effect of seven different extracts (benzene, hexane, petroleum ether, chloroform, methanol, ethanol and ethyl acetate) of M. sylvatica along with streptokinase as a positive control and water as a negative control. In the in vitro thrombolytic model, benzene, hexane, petroleum ether, chloroform, ethanol and ethyl acetate extracts showed 17.164, 17.384, 22.876, 28.984, 29.206 and 25.226% clot lysis, respectively. Among the extracts methanol extract showed significant percent of the clot lysis (46.934%) with reference to streptokinase (80.514%). From our study it was found that M. sylvatica possesses thrombolytic properties that could lyse blood clots in vitro; however, in vivo clot dissolving properties and active component (s) of M. sylvatica for clot lysis are yet to be discovered. Once discovered, M. sylvatica could be suggested as a thrombolytic agent in the treatment of patients suffering from atherothrombotic diseases.