Rates and predictors of starting a triptan: Results from the American Migraine Prevalence and Prevention Study

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Abstract

Background. - Although diagnostic rates for migraine have increased over the past 5 years, the proportion of migraine sufferers using triptans has remained essentially stable. Objectives. - To assess the rate of onset of new triptan prescriptions among persons with migraine and the predictors of initiating therapy. Methods. - The American Migraine Prevalence and Prevention Study is a longitudinal study conducted in a representative sample of headache sufferers in the US population. Episodic migraineurs not using triptans in 2005 who continued to have migraine and provided treatment data in 2006 (n = 6865) were included. We assessed predictors of triptan use in univariate and multivariate analyses, including 3 nested models. In Model 1, we adjusted for demographic variables. Model 2 added headache-related disability and cutaneous allodynia. Model 3 added depression and use of preventive headache medications. Results. - Among individuals not using triptans in 2005, triptan use in 2006 occurred in 4.9% of the sample. In unadjusted analyses, gender and race were not associated with use of triptan. Use was lower in those aged 60 years or more vs those 18-29 (odds ratio [OR] = 0.4, 95% confidence interval [CI] = 0.2-0.7, P =.001). Taking individuals with no disability as the reference, mild (OR = 1.44, 95% CI = 1.03-2.01, P =.03), moderate (OR = 1.54, 95% CI = 1.1-2.2, P =.01) and severe disability (OR = 2.19, 95% CI = 1.55-3.09, P

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Bigal, M. E., Buse, D. C., Chen, Y. T., Golden, W., Serrano, D., Chu, M. K., & Lipton, R. B. (2010). Rates and predictors of starting a triptan: Results from the American Migraine Prevalence and Prevention Study. Headache, 50(9), 1440–1448. https://doi.org/10.1111/j.1526-4610.2010.01703.x

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