Stereoselective syntheses and reactions of stannylated peptides

Abstract

In one fell swoop: Stannylated allyl carbonates allow the highly stereoselective synthesis of metalated peptides, which can be further modified by Stille coupling. Tin-iodine exchange generates iodinated peptides which also can be used for C-C coupling reactions. Therefore, only one stereoselective reaction is necessary to generate a wide range of different peptides in stereochemically pure form. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.