Nuclear Receptors and ATP Dependent Chromatin Remodeling: A Complex Story

Abstract

Nuclear receptors are a class of tightly regulated and highly inducible transcription factors and thus represent an excellent model for the study of transcription. The activity of these transcription factors is controlled by their interactions with co-regulatory proteins that act to remodel chromatin, modify histones, and initiate the transcriptional process. This review will focus on the use of nuclear receptors in understanding the role of ATP-dependent chromatin remodeling enzymes in transcription.