Identification of viable regions in "in vitro" spheroidal tumors: a mathematical investigation.

Abstract

In the treatment of solid tumors by hyperthermia, a major question is how to obtain an a priori knowledge of which tumors can be effectively treated with this modality. The key question is; given a solid tumor, what parameters in the various regions of the tumor, need to be measured so that a tumor-tissue model can provide a meaningful real time simulation of the hyperthermic treatment. This paper addresses the former question as a mathematical investigation, and the latter as a consequence of the former.