Direct cadherin-activated cell signaling

  • Yap A
  • Kovacs E
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Abstract

Classical cadherin adhesion molecules are key determinants of cell recognition and tissue morphogenesis, with diverse effects on cell behavior. Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early–immediate Rac signaling is emerging as a mechanism to coordinate cadherin–actin integration at the plasma membrane.

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Yap, A. S., & Kovacs, E. M. (2003). Direct cadherin-activated cell signaling. The Journal of Cell Biology, 160(1), 11–16. https://doi.org/10.1083/jcb.200208156

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