Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes in head and neck squamous cell carcinoma

5Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

DNA methylation has been demonstrated to play significant roles in the etiology and pathogenesis of head and neck squamous cell carcinoma (HNSCC). In the present study, methylation microarray dataset (GSE87053) and gene expression microarray dataset (GSE23558) were downloaded from GEO database and analyzed through R language. A total of 255 hypermethylated-downregulated genes and 114 hypomethylated-upregulated genes were finally identified. Functional enrichment analyses were performed and a comprehensive protein-protein interaction (PPI) network was constructed. Subsequently, the top ten hub genes selected by Cytoscape software were subjected to further analyses. It was illustrated that the expression level of CSF2, CTLA4, ETS1, PIK3CD, and CFTR was intimately associated with HNSCC. Survival analysis suggested that CTLA4 and FGFR2 could serve as effective independent prognostic biomarkers for HNSCC patients. Overall, our study lay a groundwork for further investigation into the underlying molecular mechanisms in HNSCC carcinogenesis, providing potential biomarkers and therapeutic targets for HNSCC.

References Powered by Scopus

Cancer statistics, 2016

23615Citations
N/AReaders
Get full text

The blockade of immune checkpoints in cancer immunotherapy

11047Citations
N/AReaders
Get full text

Elements of cancer immunity and the cancer-immune set point

3734Citations
N/AReaders
Get full text

Cited by Powered by Scopus

AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer

19Citations
N/AReaders
Get full text

Identification of Epigenetically Modified Hub Genes and Altered Pathways Associated With Retinoblastoma

5Citations
N/AReaders
Get full text

The Long Noncoding Transcript HNSCAT1 Activates KRT80 and Triggers Therapeutic Efficacy in Head and Neck Squamous Cell Carcinoma

5Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Jin, Y., & Qin, X. (2020). Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes in head and neck squamous cell carcinoma. Bioscience Reports, 40(1). https://doi.org/10.1042/BSR20193349

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 7

78%

Lecturer / Post doc 1

11%

Researcher 1

11%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 6

55%

Medicine and Dentistry 2

18%

Pharmacology, Toxicology and Pharmaceut... 2

18%

Agricultural and Biological Sciences 1

9%

Save time finding and organizing research with Mendeley

Sign up for free