IGRT and hypofractionation for primary tumors

Abstract

Advancements in radiation planning and delivery have resulted in the ability to safely deliver higher doses per fraction to the tumor while also sparing normal tissue. Known as hypofractionated radiation therapy (HRT), or stereotactic ablative radiation therapy (SABR), this technique has been developed in multiple sites outside the brain, including lung, prostate, and pancreas. Accompanying such treatment is some form of image guided radiation therapy (IGRT). Localization of these tumors requires high quality soft tissue imaging, in addition to the ability to ascertain tumor location during radiation delivery. This chapter will outline the role of IGRT as it pertains to HRT treatment schemes for various malignancies.