The determination of benzoic, 3-and 4-methylbenzoic, and mandelic acids in urine by gas chromatography (G.C.) is presented. The analytical procedure includes: addition of internal standard (β-naphthol), alkaline hydrolysis, ethyl ether extraction, evaporation of the solvent, and silylation of acids with Silyl-8 in pyridine (1:1). The results are calculated from ratios of the internal standard and determined metabolites peak surface areas. The coefficient of variation of the method in determination of mentioned acids is ±8%. © 1979 Springer-Verlag.
CITATION STYLE
Wieczorek, H., Trojanowska, B., & Dramiński, W. (1979). Determination of mixtures of urinary benzoic, 3- and 4-methylbenzoic, and mandelic acids by gas chromatography. Archives of Toxicology, 42(4), 281–287. https://doi.org/10.1007/BF00334842
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