Detection of mutagenicity of Vinclozolin and its epoxide intermediate

Abstract

This study examines the potential mutagenic activity of a recently developed fungicide, Vinclozolin and its epoxide metabolite. The latter shows mutagenic activity in Schizosaccharomyces Pombe and in Salmonella Typhimurium (TA 100 strain). The same test organisms showed mutagenicity of the original compound in the presence of metabolic activation obtained with rat liver microsomes treated with various inducers.