Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review)

59Citations
Citations of this article
65Readers
Mendeley users who have this article in their library.

Abstract

Pleckstrin homology-like domain, family A, member 1 (PHLDA1) encodes a member of an evolutionarily conserved pleckstrin homology-related domain protein family. It was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomas. The exact molecular and biological functions of PHLDA1 remain to be elucidated. However, its expression is induced by a variety of external stimuli and there is evidence that it may function as a transcriptional activator that acts as a mediator of apoptosis, proliferation, differentiation and cell migration dependent on the cellular type and context. Recently, PHLDA1 has received attention due to its association with cancer. In the present review, the current knowledge of PHLDA1 protein structure, expression regulation and function is summarized. In addition, the current data in the literature is reviewed with regards to the role of PHLDA1 in cancer pathogenesis.

Cite

CITATION STYLE

APA

Nagai, M. A. (2016, March 1). Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer (Review). Biomedical Reports. Spandidos Publications. https://doi.org/10.3892/br.2016.580

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free