Studies of kappa opioid receptor signaling mechanisms during the last decade have demonstrated that agonist activation of the receptor results in Gβγ-dependent signaling and distinct arrestin-dependent signaling events. Gβγ-dependent signaling results in ion channel regulation causing neuronal inhibition, inhibition of transmitter release, and subsequent analgesic responses. In contrast, arrestin-dependent signaling events result in p38 MAPK activation and subsequent dysphoric and proaddictive behavioral responses. Resolution of these two branches of signaling cascades has enabled strategies designed to identify pathway-selective drugs that may have unique therapeutic utilities. © 2014 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Chavkin, C., Schattauer, S. S., & Levin, J. R. (2014). Arrestin-mediated activation of p38 MAPK: Molecular mechanisms and behavioral consequences. Handbook of Experimental Pharmacology, 219, 281–292. https://doi.org/10.1007/978-3-642-41199-1_14
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