Colon Specific Drug Delivery by pH Sensitive Polymers & Pulsatile Drug Delivery System

Abstract

The colon is a highly vascular organ and a site where lack of digestive enzymes and long transit time occur, which provided an environment to the dosage form better systemic absorption of drug and a good bioavailability. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. This review mainly compares the primary approaches for CSDD (Colon Specific Drug Delivery) namely pH sensitive systems, and Pulsatile drug delivery system. Although oral delivery has become a widely acceptable route of administration, GI tracts presents several formidable barrier to drug delivery. In addition life cycle management, patient compliance, improved stability and optimization of drug absorption process are some key drivers for developing alternative delivery system of drugs.